Urolithin A

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evidence score

supplement

UA3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-oneMitopure+1 more

Urolithin A is a gut-derived metabolite produced from ellagitannins (found in pomegranates, walnuts, and berries) by specific gut bacteria. Only ~30-40% of the population has the gut microbiome capable of producing it in meaningful amounts — most people don't benefit from ellagitannin-rich foods. Mitopure (pharmaceutical-grade UA) provides direct supplementation bypassing gut bacteria conversion. Human RCTs show improved mitophagy biomarkers, increased muscle endurance (39% better grip endurance), reduced inflammatory markers (IL-6, TNF-alpha), and improved mitochondrial gene expression in elderly subjects. One of the most validated postbiotics in clinical development.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

1000 mg

500 mgRange2000 mg

Frequencydaily

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Pharmacology

Half-life~6 hours (plasma); tissue incorporation ongoing

OnsetMitophagy biomarker changes 4 weeks; muscle function improvements 4-8 weeks

DurationOngoing with daily supplementation

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Urolithin A is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Selective mitophagy induction via PINK1/Parkin pathway; upregulates mitochondrial biogenesis via PGC-1alpha; reduces IL-6, TNF-alpha, CRP; extends lifespan in C. elegans, rodents

Practical Context

Strongest current signals

No indexed study summaries yet.