Testosterone Enanthate

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evidence score

anabolic

Prescription Only

Test ET-enanthateDelatestryl+1 more

Testosterone Enanthate is the most widely used long-acting esterified testosterone. FDA-approved for male hypogonadism and delayed puberty. The enanthate ester provides a 7-10 day half-life, allowing once or twice-weekly injections for stable blood levels. Testosterone is the reference anabolic androgenic steroid from which all others are compared. It provides dose-dependent increases in lean mass, strength, bone density, red blood cell production, and sexual function. At TRT doses (100-200mg/week), side effects are minimal with proper monitoring. At supraphysiological doses used in bodybuilding contexts, significant cardiovascular and hormonal risks emerge. Requires AI (aromatase inhibitor) and PCT management in non-TRT protocols.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Last Sync

Not synced yet

Last Reviewed

Not reviewed yet

Physician Notes

Functionally interchangeable with cypionate. Some patients report slightly different subjective response due to ester kinetics. Same monitoring protocol applies.

FDA Status:FDA-approved for male hypogonadism.

Monitoring

Total T + Free T (trough, q3mo initially)
Hematocrit/CBC q3mo
PSA baseline + q6mo
Estradiol (sensitive) q3mo

Contraindications

Same as testosterone cypionate

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Dosing

Typical

200 mg

100 mgRange500 mg

Frequencyweekly or twice weekly

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Pharmacology

Half-life~7-10 days (ester cleavage rate)

OnsetHormonal changes within 1-2 weeks; anabolic effects peak 4-8 weeks

DurationLevels stabilize with consistent weekly dosing; effects persist during protocol

Routes

intramuscular_injection

subcutaneous_injection

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(24%)—

Quality(24%)—

Sample Size(12%)—

Consistency(14%)—

Replication(8%)—

Recency(18%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Testosterone Enanthate is currently categorized as a anabolic compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Binds androgen receptor; drives muscle protein synthesis via mTOR/PI3K/Akt; inhibits glucocorticoid receptors; erythropoietin stimulation; aromatizes to estradiol

Practical Context

Strongest current signals

No indexed study summaries yet.

Elevated caution signals

1 severe/high side effect flag