Spermidine

—

evidence score

supplement

spermidine trihydrochloridewheat germ spermidinePrimeadine

Spermidine is a naturally occurring polyamine found in all living cells, with highest dietary concentrations in wheat germ, aged cheese, mushrooms, and soy products. Endogenous spermidine levels decline sharply with age. Its primary mechanism of longevity benefit is autophagy induction — the cellular "self-cleaning" process that removes damaged proteins and organelles. Human observational data links higher dietary spermidine to reduced all-cause mortality. A clinical trial in older adults showed improved cognitive performance. Cardiovascular RCTs show blood pressure reduction and improved heart function. One of the most compelling longevity compounds based on mechanism + emerging human data.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

3 mg

1 mgRange6 mg

Frequencydaily

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~30 minutes (plasma); incorporated into polyamine pool

OnsetAutophagy induction within hours; cognitive and cardiovascular effects weeks to months

DurationOngoing with daily supplementation; polyamine pool maintained

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Spermidine is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Inhibits EP300 acetyltransferase → Nrf2 and LC3 deacetylation → autophagy induction; eIF5A hypusination for translation of specific proteins; anti-inflammatory via NF-kB suppression

Practical Context

Strongest current signals

No indexed study summaries yet.