Resveratrol

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evidence score

supplement

trans-resveratrol3,5,4'-trihydroxystilbenepterostilbene precursor+2 more

Resveratrol is a stilbenoid polyphenol found in grape skins, Japanese knotweed (highest concentration), and berries. It was catapulted to prominence by David Sinclair's work on SIRT1 activation as a potential caloric restriction mimetic. Trans-resveratrol is the active form. Bioavailability is notoriously poor with standard oral dosing (~1%) but is dramatically improved with food (particularly fat), micronized formulations, or combination with piperine. Human RCT data shows benefits for cardiovascular markers, insulin sensitivity, and cognitive function in older adults. Most potent when dosed with a meal high in fat.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

500 mg

250 mgRange2000 mg

Frequency1-2x/day with meals

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~1-3 hours (trans-resveratrol); sulfate/glucuronide conjugates persist longer

OnsetAcute metabolic effects 1-2 hours; cardiovascular/longevity effects weeks to months

DurationShort half-life requires twice-daily dosing or sustained-release form

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Resveratrol is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

SIRT1 deacetylase activation (caloric restriction mimetic); AMPK activation; NF-kB inhibition; eNOS upregulation; autophagy induction; aromatase inhibition

Practical Context

Strongest current signals

No indexed study summaries yet.