Quercetin

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evidence score

supplement

quercetin dihydratequercetin phytosomeEMIQ (enzymatically modified isoquercitrin)+1 more

Quercetin is a flavonoid polyphenol found in onions, capers, apples, and berries that has become central to longevity research as one of the most evidence-backed senolytics — compounds that selectively eliminate senescent ("zombie") cells. The Mayo Clinic/Scripps dasatinib + quercetin (D+Q) protocol is the gold standard senolytic combination, now in multiple human clinical trials. Quercetin also has strong antiviral evidence (zinc ionophore, inhibits viral replication), anti-inflammatory properties, cardiovascular protection, and AMPK activation. Bioavailability is improved by quercetin phytosome (Quercefit) or EMIQ.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

1000 mg

500 mgRange2000 mg

Frequencydaily for inflammation; intermittent (3 days on/4 weeks off) for senolytic protocol

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Pharmacology

Half-life~11-28 hours depending on form

OnsetAnti-inflammatory effects: days; senolytic protocol: cyclical (see dosing)

DurationOngoing anti-inflammatory/antioxidant; senolytic effects from intermittent protocols

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Quercetin is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Bcl-2/Bcl-xL inhibitor (senolytic); AMPK activator; SIRT1 activator; zinc ionophore; NF-kB inhibitor; 5-lipoxygenase and COX inhibitor; mast cell stabilizer

Practical Context

Strongest current signals

No indexed study summaries yet.