Pterostilbene

Pterostilbene is a naturally occurring stilbene structurally similar to resveratrol but with two methoxy groups replacing hydroxyls, resulting in dramatically better oral bioavailability (80% vs ~1% for resveratrol) and longer half-life. It activates SIRT1 more potently than resveratrol and has superior CNS penetration. Found in blueberries and grapes at low concentrations. Human studies show cognitive improvements in older adults, improved blood pressure (-5-8 mmHg), and better glycemic control. The superior pharmacokinetics make pterostilbene strictly better than resveratrol for most brain- related outcomes. Often combined with resveratrol for complementary SIRT1 activation.