Phosphatidylserine

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evidence score

nootropic

PSphosphatidyl serineSharp-PS+2 more

Phosphatidylserine (PS) is a phospholipid that is a key structural component of neuronal cell membranes, particularly concentrated in the brain. It is involved in cell signaling, apoptosis regulation, and neurotransmitter release. The FDA has granted two qualified health claims for PS: one for cognitive dysfunction and one for dementia. Human RCTs demonstrate cortisol attenuation after acute exercise stress (100mg blunts cortisol ~30%), improved memory and processing speed in elderly subjects, and benefits for ADHD symptoms in children. Originally derived from bovine brain (highest efficacy but prion risk); modern forms use soy or sunflower lecithin.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

300 mg

100 mgRange800 mg

Frequencydaily (2-3 divided doses)

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Pharmacology

Half-life~12-24 hours; incorporated into membrane for days

OnsetCortisol effects acute (single dose); cognitive effects 4-8 weeks

DurationMembrane incorporation provides sustained effects with regular dosing

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Phosphatidylserine is currently categorized as a nootropic compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Structural membrane phospholipid; activates PKC (cell signaling); inhibits cortisol release via HPA axis; supports acetylcholine and dopamine release

Practical Context

Strongest current signals

No indexed study summaries yet.