Nattokinase

—

evidence score

supplement

NKsubtilisin NATnatto enzyme+1 more

Nattokinase is a serine protease enzyme extracted from natto (fermented soybeans) with direct fibrinolytic activity — it degrades fibrin clots by the same pathway as plasmin but is stable orally. Multiple human RCTs demonstrate: reduced blood viscosity, improved blood flow velocity, reduced clotting factors (fibrinogen, PAI-1), modest blood pressure reduction, and improved cardiovascular markers. Importantly, a 2022 RCT demonstrated nattokinase reduced coronary artery calcium score progression and atherosclerotic plaque volume, making it a compelling supplement for cardiovascular risk reduction alongside vitamin K2. Often combined with serrapeptase (another fibrinolytic enzyme).

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

4000 FU

2000 FURange8000 FU

Frequency1-2x/day (away from meals)

Set height & weight in Settings to see your dose.

Pharmacology

Half-lifeActive enzyme: ~8-11 hours of fibrinolytic activity

OnsetFibrinolytic activity within 4-8 hours; cardiovascular marker improvements 4-12 weeks

DurationOngoing with daily dosing

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Nattokinase is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Direct fibrin degradation (cleaves Bβ chain); activates tissue plasminogen activator (tPA) and urokinase; degrades PAI-1; reduces blood viscosity and platelet aggregation

Practical Context

Strongest current signals

No indexed study summaries yet.