N-Acetyl Cysteine

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evidence score

supplement

NACN-acetylcysteineacetylcysteine+1 more

N-Acetyl Cysteine is the acetylated form of the amino acid cysteine and the primary rate-limiting precursor for glutathione synthesis. It is one of the most evidence-backed compounds in medicine — FDA-approved for acetaminophen overdose and mucolytic therapy, with extensive research in mental health (OCD, bipolar, addiction), PCOS, respiratory disease, liver protection, and exercise recovery. The GlyNAC (glycine + NAC) combination has shown reversal of multiple aging hallmarks in older adults in randomized trials. The FDA briefly attempted to remove NAC from the supplement market in 2021-2022 but reversed course; it remains widely available.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

1200 mg

600 mgRange2400 mg

Frequency1-2x/day

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~6 hours

OnsetGlutathione elevation within 1-2 hours; psychiatric effects weeks; longevity effects months

DurationGSH elevation persists 8-12 hours after dose; chronic benefits with daily use

Routes

oral

intravenous

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

N-Acetyl Cysteine is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Cysteine donor for glutathione synthesis; direct thiol antioxidant; mucolytic via disulfide bond cleavage; modulates glutamate signaling via cystine-glutamate antiporter

Practical Context

Strongest current signals

No indexed study summaries yet.