Magnesium L-Threonate

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evidence score

vitamin mineral

Magteinmagnesium threonateL-threonic acid magnesium+1 more

Magnesium L-Threonate is a novel form of magnesium developed at MIT specifically for its ability to cross the blood-brain barrier and increase brain magnesium levels — something other forms (glycinate, citrate, oxide) do poorly. Animal studies showed significant improvements in synaptic density, LTP (long-term potentiation), working memory, and cognitive aging reversal. Human RCTs in older adults with cognitive impairment showed significant improvements in executive function and attention. Distinct from magnesium glycinate: MgT for brain, glycinate for sleep/anxiety/muscle. Often combined.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

2000 mg

1000 mgRange2000 mg

Frequencydaily

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~2 hours (plasma); brain elevation persists 12-24 hours

OnsetSubjective sleep improvement: 1-2 weeks; cognitive effects: 4-8 weeks

DurationOngoing with consistent dosing

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Magnesium L-Threonate is currently categorized as a vitamin mineral compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Uniquely elevates cerebrospinal fluid and synaptic magnesium; increases synaptic density via NMDA receptor modulation; activates PKA/PKC signaling for synaptic plasticity

Practical Context

Strongest current signals

No indexed study summaries yet.