L-Tyrosine

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evidence score

amino acid

tyrosineL-TyrNALT (N-acetyl-L-tyrosine)

L-Tyrosine is a non-essential aromatic amino acid and the direct precursor to all catecholamines (dopamine → norepinephrine → epinephrine) and thyroid hormones (T3/T4). Its cognitive benefits are most pronounced under conditions of catecholamine depletion — stress, sleep deprivation, cold exposure, high cognitive load, and multitasking. Military research has demonstrated improved performance under adverse conditions. N-Acetyl-L-Tyrosine (NALT) has better solubility but lower conversion efficiency; plain L-tyrosine is preferred for most uses.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

2000 mg

500 mgRange4000 mg

Frequencyas needed (acute)

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~3 hours

OnsetAcute cognitive effects within 45-90 minutes; most pronounced in depleted states

Duration3-5 hours

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

L-Tyrosine is currently categorized as a amino acid compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Catecholamine synthesis precursor (DOPA decarboxylase pathway); thyroid hormone precursor; competes for large neutral amino acid transporter at BBB

Practical Context

Strongest current signals

No indexed study summaries yet.