L-Glutamine

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evidence score

amino acid

glutamineGlnL-Gln

L-Glutamine is the most abundant free amino acid in human plasma and muscle. It is conditionally essential — endogenous synthesis is adequate at rest but demand exceeds production during illness, trauma, heavy exercise, or gut compromise. It is the primary fuel source for rapidly dividing intestinal enterocytes and immune cells. Clinical evidence supports its role in gut barrier integrity, reducing intestinal permeability, supporting immune function post-surgery and during critical illness, and reducing muscle soreness after eccentric exercise. Increasingly used for gut healing protocols.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

10000 mg

5000 mgRange30000 mg

Frequency1-3x/day

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~1 hour (plasma)

OnsetGut barrier effects: days; muscle recovery effects: acute to 1 week

DurationSystemic levels normalize within hours; tissue effects require consistent dosing

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

L-Glutamine is currently categorized as a amino acid compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Primary fuel for enterocytes and lymphocytes; precursor for glutathione; maintains tight junction integrity; nitrogen transporter

Practical Context

Strongest current signals

No indexed study summaries yet.