Ginkgo Biloba

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evidence score

nootropic

EGb 761Tanakanginkgo+3 more

Ginkgo biloba is one of the most extensively studied herbs for cognitive function, with a unique combination of mechanisms targeting cerebrovascular circulation, platelet-activating factor (PAF) inhibition, and antioxidant activity. EGb 761 (standardized extract) is the most studied formulation. Meta-analyses confirm modest but significant improvements in cognitive symptoms of dementia and age-related cognitive decline. Civilian and military studies show acute cognitive benefits in healthy adults. Bilobalide has neuroprotective properties distinct from its vascular effects. One of the most used supplements globally, with a robust safety profile.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

240 mg

120 mgRange360 mg

Frequency2-3x/day

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Pharmacology

Half-lifeGinkgolides: ~3-7 hours; bilobalide: ~3 hours

OnsetCerebrovascular effects acute (1-2 hours); cognitive improvements 4-12 weeks

DurationOngoing with daily supplementation

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Ginkgo Biloba is currently categorized as a nootropic compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

PAF (platelet-activating factor) antagonism; inhibits phosphodiesterase → increased cGMP; free radical scavenging (flavonoids); inhibits EAA receptor-mediated excitotoxicity (bilobalide)

Practical Context

Strongest current signals

No indexed study summaries yet.