GHRP-6

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evidence score

gh secretagogue

Research Only

growth hormone releasing peptide 6His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide that stimulates GH release via ghrelin receptor (GHSR-1a) agonism. It was among the first synthetic GH secretagogues studied and provides some of the highest GH pulse amplitudes of the GHRP class. GHRP-6 is distinctly appetite-stimulating (strong ghrelin effect) — this is a meaningful benefit for athletes seeking mass gain but problematic for physique competitors. Compared to GHRP-2 and ipamorelin, GHRP-6 stimulates more cortisol/prolactin elevation but also drives the strongest GH pulse. Used in research and gray-market performance contexts.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Last Sync

Not synced yet

Last Reviewed

Not reviewed yet

Dosing

Typical

200 mcg

100 mcgRange300 mcg

Frequency1-3x/day (pre-workout, bedtime)

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~15-30 minutes

OnsetGH pulse begins 15-30 minutes post-injection

DurationGH pulse lasts 90-120 minutes; effects accumulate with regular use

Routes

subcutaneous_injection

intramuscular_injection

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(24%)—

Quality(24%)—

Sample Size(12%)—

Consistency(14%)—

Replication(8%)—

Recency(18%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

GHRP-6 is currently categorized as a gh secretagogue compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Ghrelin receptor (GHSR-1a) agonist in pituitary and hypothalamus; amplifies GHRH-driven GH pulse; stimulates appetite via hypothalamic NPY/AgRP neurons

Practical Context

Strongest current signals

No indexed study summaries yet.