GHRP-6

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evidence score

gh secretagogue

Research Only

growth hormone releasing peptide 6His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide that stimulates GH release via ghrelin receptor (GHSR-1a) agonism. It was among the first synthetic GH secretagogues studied and provides some of the highest GH pulse amplitudes of the GHRP class. GHRP-6 is distinctly appetite-stimulating (strong ghrelin effect) — this is a meaningful benefit for athletes seeking mass gain but problematic for physique competitors. Compared to GHRP-2 and ipamorelin, GHRP-6 stimulates more cortisol/prolactin elevation but also drives the strongest GH pulse. Used in research and gray-market performance contexts.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

200 mcg

100 mcgRange300 mcg

Frequency1-3x/day (pre-workout, bedtime)

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~15-30 minutes

OnsetGH pulse begins 15-30 minutes post-injection

DurationGH pulse lasts 90-120 minutes; effects accumulate with regular use

Routes

subcutaneous_injection

intramuscular_injection

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

GHRP-6 is currently categorized as a gh secretagogue compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Ghrelin receptor (GHSR-1a) agonist in pituitary and hypothalamus; amplifies GHRH-driven GH pulse; stimulates appetite via hypothalamic NPY/AgRP neurons

Practical Context

Strongest current signals

No indexed study summaries yet.