Fisetin

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evidence score

supplement

3,3',4',7-tetrahydroxyflavonefisetin flavonoid

Fisetin is a flavonoid found in strawberries, apples, and persimmons that has emerged as one of the most potent and bioavailable senolytic compounds — molecules that selectively eliminate senescent ("zombie") cells that accumulate with aging and drive inflammation. The Buck Institute and Mayo Clinic have identified fisetin as the most effective natural senolytic in systematic screening, with 40-50% clearance of senescent cells in aged mice resulting in significant health and lifespan improvements. Human clinical trials are active (NCT04210986 in Alzheimer's, NCT04733534 in COVID Long Haulers). Additionally has strong neuroprotective and memory-enhancing effects independent of senolytic activity.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

500 mg

100 mgRange3000 mg

FrequencySenolytic: 1000-3000mg/day × 2-3 days per month; Neuroprotective: 100-500mg/day

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~3.5-4 hours; episodic high-dose protocol preferred

OnsetSenolytic effect: single 2-3 day pulse; neuroprotective effects: weeks of daily dosing

DurationSenolytic pulses monthly; continuous low dosing for neuroprotection

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Fisetin is currently categorized as a supplement compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Bcl-2/Bcl-xL/Bcl-W inhibitor (senolytic) — selectively kills senescent cells dependent on these anti-apoptotic proteins; Nrf2 activation; SIRT1 activation; mTOR inhibition

Practical Context

Strongest current signals

No indexed study summaries yet.