Finasteride
Selectively inhibits Type II 5-alpha reductase, reducing conversion of testosterone to DHT by approximately 70%. DHT is the primary androgen responsible for miniaturization of hair follicles in androgenic alopecia. Also FDA-approved for BPH at higher doses.
Evidence
No score yet
Safety
Unknown safety profile
Clinical Status
Approved
Last Sync
Not synced yet
Last Reviewed
Not reviewed yet
Physician Notes
Topical formulations (compounded) reduce systemic DHT suppression and side effect risk. Post-finasteride syndrome is rare but real. Discuss before prescribing. Monitor DHT levels.
Monitoring
- DHT levels baseline + q6mo
- PSA (finasteride halves PSA, double the reading for screening)
- Sexual function assessment
Contraindications
- Women who are or may become pregnant
- Liver disease
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Pharmacology
Evidence Score
Plain-English Snapshot
Finasteride is currently categorized as a hormonal compound.
Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.
Safety scoring is incomplete. Start conservatively and monitor carefully.
Core mechanism
Selective Type II 5-alpha reductase inhibitor; reduces DHT by ~70% to prevent follicle miniaturization
Practical Context
Strongest current signals
No indexed study summaries yet.
Elevated caution signals
1 severe/high side effect flag