Epithalon

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evidence score

peptide

Gray Market

EpitalonepithalaminAla-Glu-Asp-Gly+1 more

Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide developed by the St. Petersburg Institute of Bioregulation and Gerontology by Prof. Vladimir Khavinson. It is derived from epithalamin (pineal gland extract) and is one of the most studied bioregulatory peptides. Russian longitudinal studies over 20+ years show reduced all-cause mortality (~50%), cancer incidence reduction, and significant lifespan extension. Its primary mechanism involves activating telomerase to elongate telomeres in somatic cells — one of very few compounds with direct telomerase-activating evidence in humans. Also normalizes circadian rhythm via pineal gland regulation. Widely used in longevity-focused protocols.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

10 mg

5 mgRange20 mg

Frequencydaily for 10-20 day cycles, 1-3x/year

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Pharmacology

Half-life~0.5-2 hours (plasma); cellular effects persist

OnsetCircadian/sleep effects within days; telomere effects accumulate over months-years

Duration2-3 cycles/year with effects accumulating over time

Routes

subcutaneous_injection

intranasal

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Epithalon is currently categorized as a peptide compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Telomerase activation via epigenetic (DNA methylation) changes; pineal gland stimulation increasing melatonin; antioxidant enzyme induction; p53/Bcl-2 apoptosis modulation

Practical Context

Strongest current signals

No indexed study summaries yet.