Clenbuterol

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evidence score

fat loss

BANNED

clenVentipulminSpiropent+1 more

Clenbuterol is a long-acting beta-2 adrenergic agonist originally developed for asthma treatment (approved in some countries for horses/livestock; not FDA-approved for human use). It is widely used in bodybuilding and weight loss communities for its thermogenic and anti-catabolic effects. Mechanism: beta-2 receptor activation increases cAMP, activating hormone-sensitive lipase in adipocytes and increasing metabolic rate by 5-10%. Also reduces skeletal muscle proteolysis. WADA prohibits it; contaminated meat has caused multiple positive doping tests. Side effect profile is significant and dose-dependent. Despite widespread use, no human RCTs specifically for fat loss exist.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

80 mcg

20 mcgRange160 mcg

Frequencydaily (in cycles of 2 weeks on/2 weeks off)

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Pharmacology

Half-life~35-40 hours

OnsetThermogenic effect within hours; body temperature elevation measurable within 1 hour

DurationHalf-life ~36 hours; effects cumulative over use period

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Clenbuterol is currently categorized as a fat loss compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Beta-2 adrenergic receptor agonist; increases cAMP via Gs → activates PKA → phosphorylates HSL (hormone-sensitive lipase) → lipolysis; thermogenic via uncoupled mitochondrial respiration

Practical Context

Strongest current signals

No indexed study summaries yet.

Elevated caution signals

1 severe/high side effect flag