Bromantane

evidence score
nootropic
Gray Market
LadastenbromantanN-(2-bromophenyl)adamantan-2-amine

Bromantane is a Soviet-era actoprotector drug developed in the late 1980s for military use under extreme heat and physical stress conditions. Unlike classical stimulants, it works by upregulating the dopamine synthesis enzyme (aromatic amino acid decarboxylase) rather than releasing or blocking reuptake of dopamine. This mechanism makes it non-addictive and less prone to tolerance. It also has unique immunostimulant properties. WADA banned it in 1996 after several positive tests. Russian clinical trials show it reduces fatigue, improves physical performance in heat, and reduces anxiety without sedation. It has a dedicated following in advanced nootropic communities for its clean energy profile.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical
50 mg
25 mgRange100 mg
Frequency1x/day (morning)

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~11 hours
OnsetAcute energy and mood effects within 1-2 hours; performance effects 1-2 weeks
DurationSingle dose effects ~12-16 hours; tolerance development slow
Routes
oral

Evidence Score

0 studies indexed
Scoring Factors
Volume(40%)
Quality(30%)
Sample Size(10%)
Consistency(10%)
Replication(5%)
Recency(5%)
Evidence Levels
AScore ≥75 with at least 1 meta-analysis and 3+ RCTs
BScore ≥50 with at least 1 RCT or meta-analysis
CScore ≥25 — observational or animal evidence only
DScore <25 — very limited or preclinical data

Plain-English Snapshot

Bromantane is currently categorized as a nootropic compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Upregulates AADC (dopa decarboxylase) gene expression; increases dopamine and serotonin synthesis capacity; non-releasing, non-reuptake mechanism; heat shock protein induction

Practical Context

Strongest current signals

No indexed study summaries yet.

Elevated caution signals

1 severe/high side effect flag

Compound Profile