Boron

—

evidence score

vitamin mineral

boron citratecalcium fructoborateboron glycinate+1 more

Boron is an essential trace mineral with emerging evidence for testosterone optimization, vitamin D activation, and bone health. A landmark study showed 10mg/day boron for 1 week increased free testosterone by 29%, reduced sex hormone binding globulin (SHBG) by 9%, and reduced estradiol by 39%. It also dramatically increases the conversion of 25(OH)D to active 1,25(OH)2D vitamin D. Most diets provide 1-3mg/day, with deficiency common in areas with boron-poor soil. Calcium fructoborate (FruiteX-B) is the best-studied food-form.

Evidence

No score yet

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Not synced yet

Dosing

Typical

10 mg

3 mgRange20 mg

Frequencydaily

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Pharmacology

Half-life~21 hours

OnsetHormonal effects within 1 week; bone effects months

DurationOngoing with daily dosing

Routes

oral

Evidence Score

—

0 studies indexed

Scoring Factors

Volume(40%)—

Quality(30%)—

Sample Size(10%)—

Consistency(10%)—

Replication(5%)—

Recency(5%)—

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Boron is currently categorized as a vitamin mineral compound.

Evidence scoring has not been fully computed yet, so interpret this profile as preliminary.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Inhibits SHBG production in liver; activates CYP27B1 for vitamin D conversion; modulates sex steroid binding; supports bone calcium retention

Practical Context

Strongest current signals

No indexed study summaries yet.