Beta-Alanine

evidence score

supplement

394 studies

β-alanineCarnoSynbeta alanine+1 more

Beta-alanine is a non-essential amino acid and the rate-limiting precursor to carnosine, a dipeptide (beta-alanine + histidine) concentrated in skeletal muscle. Carnosine acts as an intramuscular pH buffer, absorbing hydrogen ions generated during high-intensity glycolytic exercise. Beta-alanine supplementation elevates muscle carnosine by 40-80% over 4-8 weeks, consistently improving performance in exercise bouts lasting 1-4 minutes. Over 40 clinical studies support its efficacy.

Evidence

Moderate evidence

Safety

Unknown safety profile

Clinical Status

No formal phase listed

Research Sync

Feb 19, 2026

Dosing

Typical

3200 mg

2400 mgRange6400 mg

Frequencydaily in divided doses

Set height & weight in Settings to see your dose.

Pharmacology

Half-life~25 minutes (plasma); carnosine elevation persists for weeks after cessation

Onset4-8 weeks for significant carnosine loading and performance benefit

DurationCarnosine remains elevated 6-8 weeks after stopping; reloading faster on second cycle

Routes

oral

Evidence Score

Level B — Moderate

394 studies indexed · 18 meta-analyses

Scoring Factors

Volume(40%)~52/100

Quality(30%)~53/100

Sample Size(10%)~100/100

Consistency(10%)~100/100

Replication(5%)~100/100

Recency(5%)~100/100

Scores estimated from study counts. Exact breakdown computed after research sync.

Evidence Levels

AScore ≥75 with at least 1 meta-analysis and 3+ RCTs

BScore ≥50 with at least 1 RCT or meta-analysis

CScore ≥25 — observational or animal evidence only

DScore <25 — very limited or preclinical data

Plain-English Snapshot

Beta-Alanine is currently categorized as a supplement compound.

Evidence is moderate (74/100): promising signal from 394 indexed studies, but context and population still matter.

Safety scoring is incomplete. Start conservatively and monitor carefully.

Core mechanism

Rate-limiting carnosine precursor; muscle carnosine buffers intramuscular H+ ions during high-intensity glycolytic activity

Practical Context

Strongest current signals

Level A: Carnosine/histidine-containing dipeptide supplementation improves depression and quality of life: systematic review and meta-analysis of randomized controlled trials.
Level A: Beta-Alanine for Improving Exercise Capacity, Muscle Strength, and Functional Performance of Older Adults: A Systematic Review.
Level A: Effect of carnosine or beta-alanine supplementation therapy for prediabetes or type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.